G-Protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors (7TMs), are integral membrane proteins. They can be activated by external signals, such as hormones, neurotransmitters, or odors. This activation induces a conformational change of the receptor which in turn causes activation of G-proteins and the subsequent transmission of biochemical signals within the cell.

There are more than a hundred known GPCRs in humans, and many of them are involved in a broad range of diseases.

Some of these receptors are the subject of our development programs, such as the endothelin receptors ET_A and ET_B, orexin receptors OX₁ and OX₂, and the sphingosine-1-phosphate receptor S1P₁.