There is no cure for NP-C and until recently, management strategies for the disease were based on non-specific, symptomatic treatments. These therapies may be at least partially successful in treating some symptoms of NP-C, but have no impact on disease progression or long-term outcomes. Symptoms that can be treated with general therapies include, but are not limited to:

• Gelastic cataplexy - can be treated by using tricyclic antidepressants or CNS stimulants
• Dystonia - can be treated by using anti-cholinergic drugs
• Movement restrictions - can be treated by using physical therapy
• Seizures - can be controlled by using anti-epileptic drugs
• Feeding problems resulting from difficulty in swallowing - can be managed with a feeding tube

Zavesca is indicated for the treatment of progressive neurological manifestations in adult patients and pediatric patients with Niemann-Pick type C disease.